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Table 1 Genes identified from analysis of rare variant counts in combined Chinese and European ancestry data

From: Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

Gene

Model

European

p valuea

Chinese

p valueb

(Case/control)c

Combined

p valued

Combined OR (low/high)

NEK1

Dom coding

4.7 × 10–6

6.7 × 10–3 (11/2)

6.6 × 10–7

2.3 (1.6/3.2)

Dom not benign

2.2 × 10–6

5.0 × 10–2 (7/0)

3.1 × 10–7

2.9 (1.9/4.4)

Dom LoF

3.2 × 10–9

3.8 × 10–1 (2/0)

1.1 × 10–9

8.2 (3.7/20.7)

SOD1

Dom coding

7.1 × 10–8

3.7 × 10–2 (9/1)

8.9 × 10–9

9.5 (3.8/28.4)

Dom not benign

3.9 × 10–7

5.3 × 10–2 (8/1)

6.9 × 10–8

11.7 (3.9/47.5)

Dom LoF

NA

NA

NA

NA

TBK1

Dom coding

1.3 × 10–9

1.4 × 10–1 (7/1)

2.3 × 10–10

3.8 (2.4/5.9)

Dom not benign

3.6 × 10–11

1.9 × 10–1 (6/1)

8.3 × 10–12

5.9 (3.3/10.8)

Dom LoF

1.6 × 10–6

2.5 × 10–1 (1/0)

9.6 × 10–7

13.1 (3.7/70.9)

  1. aCochran–Mantel–Haenszel test (Cirulli et al., 2015) [9]
  2. bSKAT-O test [29]
  3. cNumber of Chinese case carriers and control carriers out of 610 cases and 460 controls
  4. dCochran–Mantel–Haenszel test