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Table 1 Genes identified from analysis of rare variant counts in combined Chinese and European ancestry data

From: Whole-exome sequencing in amyotrophic lateral sclerosis suggests NEK1 is a risk gene in Chinese

Gene Model European
p valuea
Chinese
p valueb
(Case/control)c
Combined
p valued
Combined OR (low/high)
NEK1 Dom coding 4.7 × 10–6 6.7 × 10–3 (11/2) 6.6 × 10–7 2.3 (1.6/3.2)
Dom not benign 2.2 × 10–6 5.0 × 10–2 (7/0) 3.1 × 10–7 2.9 (1.9/4.4)
Dom LoF 3.2 × 10–9 3.8 × 10–1 (2/0) 1.1 × 10–9 8.2 (3.7/20.7)
SOD1 Dom coding 7.1 × 10–8 3.7 × 10–2 (9/1) 8.9 × 10–9 9.5 (3.8/28.4)
Dom not benign 3.9 × 10–7 5.3 × 10–2 (8/1) 6.9 × 10–8 11.7 (3.9/47.5)
Dom LoF NA NA NA NA
TBK1 Dom coding 1.3 × 10–9 1.4 × 10–1 (7/1) 2.3 × 10–10 3.8 (2.4/5.9)
Dom not benign 3.6 × 10–11 1.9 × 10–1 (6/1) 8.3 × 10–12 5.9 (3.3/10.8)
Dom LoF 1.6 × 10–6 2.5 × 10–1 (1/0) 9.6 × 10–7 13.1 (3.7/70.9)
  1. aCochran–Mantel–Haenszel test (Cirulli et al., 2015) [9]
  2. bSKAT-O test [29]
  3. cNumber of Chinese case carriers and control carriers out of 610 cases and 460 controls
  4. dCochran–Mantel–Haenszel test