Skip to main content

Table 2 Predictive signatures for warfarin dose

From: Cohort-specific imputation of gene expression improves prediction of warfarin dose for African Americans

Cohort-specific

Generica

African American

Central European

Central European

Gene

Tissue

Gene

Tissue

Gene

Tissue

CYP1A1

Adipose, subcutaneous

ARRB1

Adipose, subcutaneous

CCND1

Adrenal gland

AKT1

Pancreas

CUBN

Adrenal gland

ABL1

Skin not-sun-exposed suprapubic

ALOX5

Adrenal gland; brain, cortex

GCLC

Spleen

ATF2

Brain, cerebellar hemisphere; brain, cerebellum

EPHX1

Heart, left ventricle; thyroid

GGCX

Brain, cerebellar hemisphere

AURKA

Brain, frontal cortex BA9

GNAI2

Whole blood

LGALS2

Pancreas

CCND1

Esophagus mucosa

ITGB1

Tibial nerve

PLCG2

Esophagus, muscularis

CUBN

Adrenal gland

LGALS2

Colon transverse

PSMA6

Skeletal muscle

CYP2C18

Liver

NCOA1

Brain, caudate basal ganglia

PTK2

Skeletal muscle

GCLM

Brain, cerebellum

PLCG2

Esophagus, muscularis; pancreas

UBE2I

Esophagus, muscularis

ITGA2B

Thyroid

PROZ

Spleen

VKORC1

Liver; thyroid

JUN

Tibial artery

SERPINF2

Thyroid

  

MGP

Esophagus gastroesophageal junction

SMAD3

Esophagus, mucosa

  

PSEN1

Pituitary

STX4

Colon transverse

  

SMAD2

Testis

VKORC1

Liver

  

VKORC1

Thyroid; heart atrial appendage

  1. aThe generic methods did not produce a signature on the AA training cohort