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Table 1 Emerging pathways in neuroimaging-genomics studies

From: Neuroimaging genomics in psychiatry—a translational approach

Neural phenotype Clinical manifestations Enriched pathways Examples of studies that identified these associated pathways in humans
Subcortical brain volumes On average, hippocampal volumes are smaller in patients with depression [176], bipolar disorder [177], and schizophrenia [178] compared with healthy controls • Neurodevelopment
• Synaptic signaling
• Ion transport and storage
• Axonal transport
• Neuronal apoptosis
• Neural growth
• Neural differentiation
• Immune pathways
Hibar et al. 2015, 2017 [4, 44]
Brain connectivity Brain white matter microstructure is disrupted globally in schizophrenia [179] • ATP synthesis and metabolism
• Axon guidance
• Fasciculation during development
Fornito et al. 2015 [133]
Vértes et al. 2016 [134]
Transcriptional profiles Transcription factor EGR1 significantly downregulated in brains of schizophrenic patients compared with controls [180] • Ion channels
• Synaptic activity
• ATP metabolism
Wang et al. 2015 [136]
Richiardi et al. 2015 [137]