Fig. 3

The densities of the proportion of risk genes (x-axis) and mean relative risk (y-axis) for ASD, EPI, ID, and DD data. These were obtained after 20,000 iterations of three MCMC chains. For ASD, there are two de novo classes and one case–control class. For other disorders, only two de novo classes are publicly available for our current study. The scales on the y-axes are adjusted because mean relative risk varies between categories and disorders. ASD autism spectrum disorders, DD developmental disorder, EPI epilepsy, ID intellectual disability, LoF loss of function, MCMC Markov chain Monte Carlo, MiD missense damaging