|
Parameter
|
Estimated
|
Lower credible
|
Upper credible
|
|---|
| |
mode
|
interval boundary
|
interval boundary
|
|---|
|
SCZ_pi (%)
|
8.01
|
4.59
|
12.9
|
|
SCZ_meanRR_silentFCPk_denovo
|
1.22
|
1.00
|
2.16
|
|
SCZ_meanRR_MiD_denovo
|
1.44
|
1.00
|
3.16
|
|
SCZ_meanRR_LoF_denovo
|
12.25
|
4.79
|
22.22
|
|
SCZ_meanRR_MiD+LoF_CCpop1
|
2.09
|
1.04
|
3.54
|
|
SCZ_meanRR_MiD+LoF_CCpop2
|
2.44
|
1.05
|
5.73
|
|
SCZ_meanRR_MiD+LoF_CCpop3
|
1.04
|
1
|
1.19
|
|
ASD_pi (%)
|
4.44
|
3.15
|
5.94
|
|
ASD_meanRR_MiDdenovo
|
3.71
|
2.06
|
8.71
|
|
ASD_meanRR_LoFdenovo
|
24.56
|
14.27
|
37.44
|
|
ASD_meanRR_LoFcc
|
4.04
|
2.08
|
8.24
|
|
ID_pi (%)
|
2.53
|
1.89
|
3.43
|
|
ID_meanRR_MiDdenovo
|
29.82
|
18.86
|
46.1
|
|
ID_meanRR_LoFdenovo
|
105.45
|
73.27
|
143.29
|
|
DD_pi (%)
|
2.84
|
2.29
|
3.45
|
|
DD_meanRR_MiDdenovo
|
23.42
|
13.97
|
33.97
|
|
DD_meanRR_LoFdenovo
|
88.32
|
67.54
|
115.09
|
|
EPI_pi (%)
|
1.14
|
0.52
|
2.1
|
|
EPI_meanRR_MiDdenovo
|
72.2
|
35.39
|
128.46
|
|
EPI_meanRR_LoFdenovo
|
89.71
|
45.31
|
169.43
|
- These results were obtained by sampling three MCMC chains (20,000 times for each chain). These results are for three categories: loss of function (LoF) variants/mutations, missense damaging (MiD) variants/mutations, and silent within frontal cortex-derived DHS peaks (silentFCPk) variants.
-
ASD autism spectrum disorders, CC case–control, DD developmental disorder, DN de novo, EPI epilepsy, ID intellectual disability, LoF loss of function, MCMC Markov chain Monte Carlo, MiD missense damaging, NDD neurodevelopmental disorder, SCZ schizophrenia, silentFCPk silent within frontal cortex-derived DHS peaks
