Table 2 Enrichment of known gene sets from extTADA results for schizophrenia
Gene set | Gene number | Overlapping gene number | p value | FDR |
|---|---|---|---|---|
Constrained | 1003 | 939 | 3.3e-06 | 6.2e-04 |
pLI09 | 3488 | 3241 | 1.0e-05 | 8.2e-04 |
rbfox2 | 3068 | 2895 | 1.3e-05 | 8.2e-04 |
chd8.human_brain | 2798 | 2601 | 5.0e-05 | 2.3e-03 |
rbfox13 | 3445 | 3230 | 1.7e-04 | 6.3e-03 |
FMRP_targets | 839 | 792 | 2.1e-04 | 6.5e-03 |
celf4 | 2675 | 2468 | 2.7e-04 | 7.1e-03 |
Module.M3 | 162 | 145 | 5.6e-04 | 1.3e-02 |
DD.allDenovoMiDandLoF | 1271 | 1271 | 7.0e-04 | 1.4e-02 |
ARC | 28 | 25 | 1.0e-03 | 1.8e-02 |
NMDAR_network | 61 | 58 | 1.5e-03 | 2.3e-02 |
abnormal_emotionORaffect_behavior | 392 | 363 | 1.5e-03 | 2.3e-02 |
AlleleBiasedExpression.Neuron | 802 | 619 | 1.9e-03 | 2.6e-02 |
Module.M13 | 149 | 129 | 2.0e-03 | 2.6e-02 |
abnormal_cued_conditioning_behavior | 74 | 67 | 2.5e-03 | 2.9e-02 |
mGluR5 | 39 | 36 | 2.4e-03 | 2.9e-02 |
abnormal_sensory_capabilitiesORreflexesORnociception | 607 | 579 | 4.5e-03 | 4.9e-02 |
mir137 | 3260 | 2940 | 7.0e-03 | 6.5e-02 |
abnormal_behavior | 2037 | 1937 | 7.0e-03 | 6.5e-02 |
Pardinas2017_extTable9 | 534 | 522 | 7.0e-03 | 6.5e-02 |
PSD-95_(core) | 65 | 57 | 8.0e-03 | 6.7e-02 |
abnormal_excitatory_postsynaptic_currents | 73 | 67 | 8.0e-03 | 6.7e-02 |
list.EPI.43genes.2017.Epi4K.2017 | 43 | 38 | 9.2e-03 | 7.2e-02 |
abnormal_socialORconspecific_interaction | 257 | 238 | 9.4e-03 | 7.2e-02 |
abnormal_associative_learning | 204 | 190 | 1.5e-02 | 1.1e-01 |
abnormal_social_investigation | 64 | 54 | 1.8e-02 | 1.2e-01 |
Module.M1 | 1244 | 1071 | 1.8e-02 | 1.2e-01 |
synaptome | 1887 | 1816 | 1.9e-02 | 1.3e-01 |
abnormal_motor_capabilitiesORcoordinationORmovement | 1398 | 1326 | 2.0e-02 | 1.3e-01 |
CYFIP1_all | 37 | 34 | 2.1e-02 | 1.3e-01 |
abnormal_fearORanxiety-related_behavior | 232 | 213 | 2.3e-02 | 1.4e-01 |
abnormal_behavioral_response_to_xenobiotic | 219 | 208 | 3.0e-02 | 1.7e-01 |
abnormal_learningORmemoryORconditioning | 449 | 414 | 3.1e-02 | 1.7e-01 |
abnormal_brain_size | 193 | 180 | 3.6e-02 | 1.8e-01 |
abnormal_contextual_conditioning_behavior | 95 | 88 | 3.4e-02 | 1.8e-01 |
abnormal_excitatory_postsynaptic_potential | 64 | 58 | 3.5e-02 | 1.8e-01 |
abnormal_aggression-related_behavior | 69 | 62 | 3.7e-02 | 1.8e-01 |
Module.M2 | 38 | 35 | 4.1e-02 | 2.0e-01 |
abnormal_discrimination_learning | 21 | 20 | 4.3e-02 | 2.0e-01 |