Fig. 5

Performance of the serum DNAme marker panel in a population-based cohort for early OC diagnosis. Compared to the prospectively collected samples within the EpiFemCare Programme, UKCTOCS samples contained a significantly higher DNA concentration (a) and larger average DNA fragment size (b). As a result of this, we had to lower the cut-off for the three markers by a factor three (i.e. pattern frequency cut-off for #141, #204, and #228 is 0.00027, 0.00001, and 0.0000033, respectively). For OC Set 2, we only display the result of the 50 samples for which we have analyzed both DNA amount and fragment size (for 42 samples, we only analyzed DNA amount). In addition, in one UKCTOCS sample, the fragment size analysis failed. ***p < 0.001