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Table 1 Specificities and sensitivities to discriminate high grade serous ovarian cancers from healthy and benign pelvic mass. Based on Serum Set 1&2 analyses cut-off thresholds of 0.0008, 0.0001 and 0.0001 for regions #141, #204 and #228, respectively, to discriminate HGS OC from H or BPM women were chosen and validated in Set 3. Combining Serum Sets 1-3 (note #228 was not analyzed in Set 1) the cut-off thresholds have been refined so that the final cut-offs for #141, #204 and #228 were 0.0008, 0.00003 and 0.00001 respectively; the sample was called positive if at least one of the three regions showed a pattern frequency above the cut-off. 95% CI, 95% Confidence Interval; DNAme, DNA methylation

From: The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer

  Specificity Sensitivity
Set 3 CA125 (cut-off 35 IU/mL) 122/140 (87.1%; 95% CI = 80.1–92.0%) 24/29 (82.8%; 95% CI = 63.5–93.5%)
3 DNAme-Marker Panel (thresholds based on Sets 1 and 2) 127/140 (90.7%; 95% CI = 84.3–94.8%) 12/29 (41.4%; 95% CI = 24.1–60.9%)
Set 2 & 3 3 DNAme-Marker Panel (new thresholds based on Sets 1, 2, and 3) 178/194 (91.8%, 95% CI = 86.7–95.1%) 28/48 (58.3%; 95% CI = 43.2–72.1%)