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Table 4 Specificity and sensitivity to detect OC in pre-diagnostic UKCTOCS samples are shown for the complete sample set (A), as well as for samples split according to DNA concentration below (low DNA) (B) and above (high DNA) (C) the median and with a CA125 concentration < 35 IU/mL (CA125-negative samples) in the three groups. Definitions of DNA methylation positivity are provided in Table 1

From: The potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer

(A) All samples CA125-negative samples
0–2 years 0–1 years 1–2 years 0–2 years 0–1 years 1–2 years
Specificity (CI%) 96.9% (90.8–98.6) 96.9% (90.8–98.6) 96.9% (90.8–98.6) 96.8% (91.5–99) 96.8% (91.5–99) 96.8% (91.5–99)
Sensitivity (CI%) 23.3% (12.3–39) 31.6% (13.6–56.5) 16.7% (5.5–38.2) 15.4% (5–35.7) 22.2% (3.9–59.8) 11.8% (2.1–37.8)
(B) Low DNA samples CA125-negative samples
0–2 years 0–1 years 1–2 years 0–2 years 0–1 years 1–2 years
Specificity (CI%) 88.1% (77.3–94.3) 88.1% (77.3–94.3) 88.1% (77.3–94.3) 87.5% (76.3–94.1) 87.5% (76.3–94.1) 87.5% (76.3–94.1)
Sensitivity (CI%) 57.9% (34.0–78.9) 55.6% (22.7–84.7) 60.0% (27.4–86.3) 63.6% (31.6–87.6) 66.7% (24.1–94.0) 60% (17.0–92.7)
(C) High DNA samples CA125-negative samples
0–2 years 0–1 years 1–2 years 0–2 years 0–1 years 1–2 years
Specificity (CI%) 90.3% (79.5–96) 90.3% (79.5–96) 90.3% (79.5–96) 90.2% (79.2–95.9) 90.2% (79.2–95.9) 90.2% (79.2–95.9)
Sensitivity (CI%) 12.5% (3.3–33.5) 30% (8.1–64.6) 0% (0–26.8) 0% (0–25.3) 0% (0–69) 0% (0–30.1)