Fig. 4

Variability of drug risk probabilities across populations. a Number of drugs with shared (black) or separate (colored) drug risk probabilities (DRP) for functional variants in their pharmacological target genes greater than 1%. DRP scores were calculated by aggregating the risk of functional variation across all documented pharmacological target genes of that drug. b Drugs with highest (top) or lowest (bottom) mean DRP difference compared to all other populations, indicating which population is at higher/lower risk of encountering functional variation in the target for a drug and thus higher/lower impact on drug effect