Fig. 1

Overlap between genome-wide significant AD risk variants and DNase hypersensitivity sites from 38 tissues profiled by the Roadmap Epigenomics Project. AD risk variants and 10,000 sets of matched SNPs were intersected with DNase hypersensitivity sites. Z scores were calculated for the AD risk variants set for each tissue type. The x-axis is the z score and the y-axis the tissue types. Box plots indicate the distribution of overlap from the 10,000 background matched SNP sets. Tissue have been coded as blood (green), brain (blue) and other (orange). Red circles are the z scores for the AD risk variants set. P values were calculated from the observed overlap of the 10,000 background matched SNP sets. P values are corrected using the method described by Benjamini and Hochberg [24]. AD Alzheimer’s disease, SNP single nucleotide polymorphism. ***P < 0.005, **P < 0.01