Skip to main content

Advertisement

Table 1 Enrichment of AD heritability at variants within EGR1, CEBPA, MEF2A, SPI1 and no-motif-containing macrophage DNase hypersensitivity sites

From: Genetic risk for Alzheimer’s disease is concentrated in specific macrophage and microglial transcriptional networks

DHS motif set Enrichment Enrichment P value Corrected P value
EGR1 14.481 1.03 × 10− 4 5.14 × 10− 4
CEBPA 9.716 6.86 × 10− 4 3.43 × 10−3
SPI1 8.933 2.43 × 10−3 0.012
MEF2A 19.222 4.46 × 10−3 0.022
No-motif 7.661 0.125 0.623
  1. AD heritability was partitioned by transcription factor motif-containing DNase hypersensitivity sites using LDscore regression [12]. AD heritability was significantly enriched (after correcting for multiple testing) at all four transcription factor motif-containing DNase hypersensitivity sites but not the no-motif set
  2. AD Alzheimer’s disease