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Fig. 2 | Genome Medicine

Fig. 2

From: Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Fig. 2

A cross-cohort meta-analysis finds little evidence of autism-associated methylomic variation in neonatal and childhood blood samples. a Manhattan plot of P values from the autism EWAS meta-analysis (total n = 2917). P values were calculated using Fisher’s method for combining P values; solid circles indicate sites where the direction of effect was consistent across all contributing cohorts, empty triangles indicate where there were different directions of effect in at least two studies. The red horizontal line indicates experiment-wide significance (P < 1 × 10−7). The blue horizontal line indicates a more relaxed "discovery" threshold (P < 1 × 10−5). b Forest plot of cg03618918, the most significant DNA methylation sites associated with ASD in the meta-analysis. The effect is the mean difference in DNA methylation between autism cases and controls. The sizes of the boxes are proportional to the sample size of that cohort

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