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Fig. 3 | Genome Medicine

Fig. 3

From: Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Fig. 3

Polygenic burden for autism is associated with significant variation in DNA methylation at birth. a Density plot of polygenic risk score (PRS; pT = 0.01) split by ASD case control status. b Q-Q plots of the ASD PRS (pT = 0.01) EWAS analysis in neonatal blood DNA. c Manhattan plot of the ASD PRS (pT = 0.01) EWAS analysis in neonatal blood DNA. The red horizontal line indicates experiment-wide significance (P < 1 × 10−7); blue horizontal line indicates a “discovery” significance threshold (P < 5 × 10−5). Scatterplots of experiment-wide significant CpG sites where DNA methylation (y-axis) at d cg02771117 and e cg27411982 is correlated with ASD PRS (x-axis). Red points indicate ASD cases, green points indicate controls. f Scatterplots of –log10 P value from the EWAS of ASD PRS comparing the results from an analysis performed in all individuals (x-axis) against the results from an analysis performed separately for cases and controls and then combined with a meta-analysis (y-axis)

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