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Fig. 1 | Genome Medicine

Fig. 1

From: From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards

Fig. 1

Overview of the pipeline to report actionable variants from tumor genomic profiles. a The algorithm uses two types of input: type of tumor (e.g., breast cancer) and its genomic profile (i.e., somatic variants). b First, the genomic profile is used to identify the actionable variants as depicted in the flowchart. A variant with an established significance will follow the central path of the flowchart (e.g., BRAF V600E). The side arms are designed to repurpose variants of unknown significance. c Then, the actionable variants are classified into clinically relevant categories using a system of six levels of evidence. d Finally, the output is in form of hand-in reports

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