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Table 1 Main characteristics of the public databases of predictive biomarkers

From: From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards

 

GDKD

CIViC

TARGET

Number of genes

170

290

135

Number of predictive genes

Total

170

213

111

Exclusive

46

105

10

Common

79

Number of variant–drug associations

618

1931

111

Number of cancer types

65

177

Not specified

Biomarker types

Predictive

Predictive

Predictive

Prognostic

Prognostic

Diagnostic

Diagnostic

Clinical significance levels

Response

Sensitivity

Free text

Sensitivity

Resistance or non-response

Increased benefit

No response

No sensitivity

Reduced/decreased sensitivity

Resistance

Evidence levels

NCCN/FDA

A: clinical routine

None

Late trials

B: clinical trials

Early trials

C: case reports

Case report

D: preclinical

Preclinical

E: inferential

Variant specific

Yes

Yes

No

References provided

Yes

Yes

No

Version

v19

1 June 2017

v3

Source

[20]

[21]

[12]

  1. Each column summarizes the specificities of each database: GDKD Gene Drug Knowledge Database, CIViC Clinical Interpretation of Variants in Cancer, TARGET Tumor Alterations Relevant for Genomics-driven Therapy