TY - JOUR AU - Sekiya, Michiko AU - Wang, Minghui AU - Fujisaki, Naoki AU - Sakakibara, Yasufumi AU - Quan, Xiuming AU - Ehrlich, Michelle E. AU - De Jager, Philip L. AU - Bennett, David A. AU - Schadt, Eric E. AU - Gandy, Sam AU - Ando, Kanae AU - Zhang, Bin AU - Iijima, Koichi M. PY - 2018 DA - 2018/03/29 TI - Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models JO - Genome Medicine SP - 26 VL - 10 IS - 1 AB - Cerebral amyloidosis, neuroinflammation, and tauopathy are key features of Alzheimer’s disease (AD), but interactions among these features remain poorly understood. Our previous multiscale molecular network models of AD revealed TYROBP as a key driver of an immune- and microglia-specific network that was robustly associated with AD pathophysiology. Recent genetic studies of AD further identified pathogenic mutations in both TREM2 and TYROBP. SN - 1756-994X UR - https://doi.org/10.1186/s13073-018-0530-9 DO - 10.1186/s13073-018-0530-9 ID - Sekiya2018 ER -