Fig. 7

Gene regulatory network analysis of gene expression signatures in tau/TREM2/TYROBP flies with human AD WGCNA. a Overlap between HBTRC or ROSMAP human AD WGCNA co-expression network modules and DEGs identified in (Additional file 1: Figures S3A and S4B). b Causal regulatory network of the genes from two inflammatory response modules “salmon” and “lightcyan” identified from the ROSMAP human AD WGCNA co-expression network. DEGs in at least one of the present fly transgenic models are denoted by red color, otherwise by cyan color. Genes having fly orthologs are in eclipse shape, otherwise in diamond shape. Node size is proportional to the number of downstream genes. Genotypes of flies are described in Additional file 2: Table S1