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Fig. 1 | Genome Medicine

Fig. 1

From: Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations

Fig. 1

Cancer Genome Interpreter. a Outline of the CGI workflow. With a list of genomic alterations as input, the CGI automatically recognizes the format, remaps the variants as needed, and standardizes the annotation for downstream compatibility. All analyses are cancer-specific and thus the tumor type of the sample(s) to analyze is also required. Next, the CGI identifies known driver alterations and annotates and classifies the remaining variants of unknown significance. Finally, alterations that are biomarkers of drug effects are identified. b The CGI may be run via the web at http://www.cancergenomeinterpreter.org (left panel) or through an API. The web results can be stored in a private repository (right panel) for their management. The results of the CGI are provided via interactive reports. c An example of a mutation analysis report. This contains the annotations of all mutations, which empowers the user’s review, and the labels for those known or predicted to be drivers by OncodriveMUT. d An example of a biomarker match report. This contains the putative biomarkers of drug response found in the tumor organized according to distinct levels of clinical relevance. All these web reports are interactive and configurable by the user. CNA copy number alteration

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