Fig. 2

Reconstruction of mutational profiles using known mutational signatures. a The optimal relative contribution of COSMIC signatures to reconstruct the mutational profiles of the samples. The signatures with at least 10% contribution in at least one of the samples are plotted. b Cosine similarity between the original mutational profile and the reconstructed mutational profile based on the optimal linear combination of all 30 COSMIC signatures. The line indicates the threshold of cosine similarity = 0.95. c Relative contribution of each of the 96 trinucleotide changes to the original mutational profile (upper panel) and the reconstructed mutational profile (middle panel), and the difference between these profiles (lower panel) for the ASC with the lowest cosine similarity (1-a). The residual sum of squares (RSS) and the cosine similarity between the original and the reconstructed mutational profile are indicated