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Fig. 3 | Genome Medicine

Fig. 3

From: MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Fig. 3

Transcriptional strand bias and genomic distribution. a Mutational signatures with transcriptional strand information. The relative contribution of each trinucleotide change, subdivided into the fraction of trinucleotide changes present on the transcribed (T, light shades) and untranscribed strand (U, dark shades) b Log2 ratio of the number of mutations on the transcribed and untranscribed strand per indicated base substitution for each signature depicted in a. The log2 ratio indicates the effect size of the bias and asterisks indicate significant transcriptional strand asymmetries (P < 0.05, two-sided binomial test). c Log2 ratio of the number of mutations on the transcribed and untranscribed strand per indicated base substitution for each tissue type. Asterisks indicate significant transcriptional strand asymmetries (P < 0.05, two-sided Poisson test) d Enrichment and depletion of somatic point mutations in the promoter regions, gene bodies and intergenic genomic regions for all tissues. The log2 ratio of the number of observed and expected point mutations indicates the effect size of the enrichment or depletion in each region. Asterisks indicate significant enrichments or depletions (P < 0.05, one-sided binomial test). e Rainfall plot showing the genomic location of mutations, intermutation distance and the mutation types for sample 14-b

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