Skip to main content
Fig. 2 | Genome Medicine

Fig. 2

From: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Fig. 2

CoGAPS analysis identifies signatures of resistance to EGFR inhibitors and separate resistant and control generations. a Heatmap of gene expression values in 11 generations of SCC25 cells treated with 100 nM of cetuximab (red columns) to acquire resistance and with PBS as control (black columns). b Heatmap of gene expression values for PatternMarker genes identified with CoGAPS analysis of gene expression data from 11 generations of SCC25 cells treated with PBS as control (black columns) and with 100 nM of cetuximab (red columns) to acquire resistance. Rows are colored according to which CoGAPS pattern the PatternMarker statistic assigned each gene and sorted by the PatternMarker statistic. c CoGAPS patterns inferred from gene expression data over generations of PBS control (black lines) or treatment with 100 nM of cetuximab (red lines)

Back to article page