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Fig. 7 | Genome Medicine

Fig. 7

From: Integrated time course omics analysis distinguishes immediate therapeutic response from acquired resistance

Fig. 7

FGFR1 gene expression and DNA methylation patterns were confirmed in independent HNSCC tumor sample datasets. a Scatter plot of gene expression for EGFR and FGFR1 in HPV-negative HNSCC samples from TCGA demonstrated that only a few HNSCC cases present increased levels of both genes and that there is no significant correlation between the expression of both genes concomitantly. b DNA methylation of FGFR1 was anti-correlated with expression in HPV-negative HNSCC TCGA samples, suggesting that upregulation of FGFR1 might be a result of promoter demethylation in primary tumors. c EGFR expression was significantly overexpressed in a group of HNSCC patients with LPFS relative to patients with SPFS in gene expression data from Bossi et al. d FGFR1 was significantly overexpressed in patients with SPFS relative to patients with LPFS in this same dataset. LPFS - long-progression-free survival; SPFS - short-progression-free survival

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