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Fig. 2 | Genome Medicine

Fig. 2

From: A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing

Fig. 2

cisFusion calls. cisFusion evaluation for cell lines and frozen clinical samples (a) and for FFPE clinical samples (b). The y-axis represents the signal-to-noise (S/N) ratio: the ratio of the number of support reads for a correct fusion gene to the number of support reads for an incorrectly detected fusion candidate with the largest number of support reads. S/N > 1, shown with the red broken line, indicates that correct fusions are ranked at the top. The normalized support read count in the y-axis represents the number of support reads for a correct fusion divided by the number of all mapped reads. The asterisks indicate datasets where the target panels were designed to capture one gene of a fusion pair; otherwise, the panels were designed to capture both genes. The details of datasets and panels are presented in Additional file 1: Table S1. Sqcr sequencer. c IGV [33] screenshot showing an example of support reads in an FFPE sample for a fusion detected by cisFusion but missed by FusionMap

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