Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers

Table 1 Comparison of the performance of different methylation markers for classifying HCC and normal tissues

Markers	Two HCC-specific CpGs	Six HCC-specific CpGs	Nine CpGs of Zheng et al.^a	Seven CpGs of Xu et al.^b
Sensitivity
GSE54503	0.848	0.909	0.970	0.833
GSE89852	0.892	0.919	0.919	0.946
GSE56588	0.920	0.924	0.942	0.741
Specificity
GSE54503	0.970	0.970	0.970	0.955
GSE89852	0.973	0.973	0.892	0.919
GSE56588	1.000	1.000	1.000	1.000

^aZheng et al. [16] reported ten CpGs as HCC diagnostic markers. Nine of them had methylation values in TCGA HCC dataset
^bXu et al. [17] reported ten CpGs as HCC diagnostic markers. Seven of them had methylation values in TCGA HCC dataset

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