Table 2 Comparison of the cellular population structure (AD vs neuropath-free controls) from the brains in the Mayo Clinic and Mount Sinai Brain Bank
Brain regions | Sample size | Neuron | Astrocyte | Oligodendrocyte | Microglia | |||||
|---|---|---|---|---|---|---|---|---|---|---|
n | Effect | p value | Effect | p value | Effect | p value | Effect | p value | ||
Mayo | AD vs Control | |||||||||
CB | 119 | − 0.03 | 2.74 × 10−01 | 0.05 | 8.65 × 10−02 | − 0.02 | 1.07 × 10−01 | −3.19 × 10−04 | 9.19 × 10−01 | |
TC | 119 | − 0.17 | 1.58 × 10−07 | 0.23 | 5.01 × 10−09 | − 0.07 | 1.8 × 10−02 | − 2.03 × 10−03 | 5.48 × 10−01 | |
Mount Sinai Brain Bank | AD vs Control | |||||||||
APC | 184 | − 0.04 | 8.14 × 10−04 | 0.06 | 8.11 × 10−05 | − 0.01 | 3.36 × 10−02 | − 3.18 × 10−03 | 1.12 × 10−02 | |
STG | 167 | − 0.08 | 3.49 × 10−07 | 0.1 | 1.45 × 10−07 | − 0.01 | 5.8 × 10−02 | − 3.17 × 10−03 | 5.78 × 10−02 | |
PHG | 160 | − 0.11 | 1.35 × 10−08 | 0.13 | 5.48 × 10−10 | − 0.02 | 1.79 × 10−03 | − 3.18 × 10−03 | 1.35 × 10−01 | |
IFG | 159 | − 0.04 | 3.12 × 10−03 | 0.06 | 3.58 × 10−04 | − 0.01 | 4.39 × 10−02 | −3.98 × 10−03 | 1.64 × 10−02 | |
Clinical Dementia Rating | ||||||||||
APC | 184 | − 0.02 | 9.38 × 10−04 | 0.02 | 2.07 × 10−04 | − 3.43 × 10−03 | 1.25 × 10−01 | − 1.46 × 10−03 | 4.95 × 10−03 | |
STG | 167 | − 0.03 | 1.87 × 10−06 | 0.04 | 3.33 × 10−07 | − 0.01 | 2.1 × 10−02 | −1.02 × 10−03 | 1.49 × 10−01 | |
PHG | 160 | − 0.04 | 8.56 × 10−06 | 0.04 | 2.85 × 10−06 | − 0.01 | 8.7 × 10−02 | − 1.94 × 10−03 | 2.53 × 10−02 | |
IFG | 159 | − 0.02 | 8.29 × 10−05 | 0.03 | 1.4 × 10−05 | − 4.64 × 10−03 | 6.7 × 10−02 | − 1.46 × 10−03 | 3.11 × 10−02 | |
Braak staging | ||||||||||
APC | 173 | − 0.01 | 1.21 × 10−02 | 0.01 | 1.27 × 10−03 | − 3.09 × 10−03 | 2.77 × 10−02 | − 7.04 × 10−04 | 3.12 × 10−02 | |
STG | 158 | − 0.02 | 2.22 × 10−07 | 0.02 | 2.77 × 10−07 | − 2.91 × 10−03 | 1.17 × 10−01 | − 5.47 × 10−04 | 1.97 × 10−01 | |
PHG | 147 | − 0.02 | 1.83 × 10−06 | 0.03 | 9.6 × 10−08 | − 0.01 | 1.49 × 10−03 | − 3.71 × 10−04 | 4.97 × 10−01 | |
IFG | 152 | − 0.01 | 1.01 × 10−02 | 0.01 | 8.56 × 10−04 | − 3.55 × 10−03 | 2.37 × 10−02 | − 1.01 × 10−03 | 1.74 × 10−02 | |
Mean amyloid plaques | ||||||||||
APC | 184 | −1.88 × 10−03 | 3.6 × 10−03 | 2.82 × 10−03 | 1.03 × 10−04 | − 7.99 × 10−04 | 2.13 × 10−03 | − 1.46 × 10−04 | 1.72 × 10−02 | |
STG | 167 | −4.2 × 10−03 | 7.73 × 10−08 | 0.01 | 4.63 × 10−08 | − 6.08 × 10−04 | 9.01 × 10−02 | − 2.04 × 10−04 | 1.5 × 10−02 | |
PHG | 160 | − 4.96 × 10−03 | 5.05 × 10−09 | 0.01 | 1.26 × 10−10 | − 9.99 × 10− 04 | 1.85 × 10−03 | − 2.1 × 10−04 | 2.58 × 10−02 | |
IFG | 159 | −2.58 × 10−03 | 3.82 × 10−04 | 3.53 × 10−03 | 1.96 × 10−05 | − 7.41 × 10−04 | 1.51 × 10−02 | − 2.04 × 10−04 | 1.26 × 10−02 | |