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Table 3 Cellular population structure altered in the parietal lobe from AD brains in the DIAN study and Knight-ADRC brain bank

From: Genetic variants associated with Alzheimer’s disease confer different cerebral cortex cell-type population structure

Disease status Sample size Neuron Astrocyte Oligodendrocyte Microglia
  n Effect p value Effect p value Effect p value Effect p value
AD status
 ADa vs Control 122 − 0.11 5.52 × 10−04 0.14 2.48 × 10−05 − 0.03 6.5 × 10−02 − 2.64 × 10−03 2.49 × 10−01
 ADAD vs Control 38 − 0.19 3.94 × 10−07 0.24 1.57 × 10−10 − 0.04 8.5 × 10−03 − 0.01 7.77 × 10−05
 LOAD vs Control 100 − 0.09 5.67 × 10−03 0.12 3.34 × 10−04 − 0.02 1.06 × 10−01 − 1.70 × 10−03 4.57 × 10−01
 ADAD vs LOAD
  Braak matched 42 − 0.08 1.03 × 10−02 0.11 9.26 × 10−04 − 0.03 7.1 × 10−02 − 1.46 × 10−03 7.01 × 10−01
  Braak corrected 91 − 0.09 4.71 × 10−03 0.11 5.24 × 10−04 − 0.02 1.77 × 10−01 − 2.41 × 10−03 4.25 × 10−01
  CDR corrected 94 − 0.12 2.11 × 10−03 0.13 6.29 × 10−04 − 0.02 3.8 × 10−01 − 3.11 × 10−03 2.41 × 10−01
Clinical Dementia Rating
 ADa and Controls 110 − 0.02 2.66 × 10−02 0.03 5.48 × 10−03 − 0.01 2 × 10−01 − 4.63 × 10−04 4.77 × 10−01
 ADAD and Controls 26 − 0.08 4.12 × 10−04 0.11 1.78 × 10−07 0.01 4.03 × 10−03 − 1.55 × 10−03 1.75 × 10−08
 LOAD and Controls 100 − 0.02 3.22 × 10−02 0.03 7.01 × 10−03 − 0.01 1.81 × 10−01 − 4.64 × 10−04 5.11 × 10−01
Braak staging
 ADa and Controls 106 − 0.03 8.51 × 10−06 0.03 3.83 × 10−06 − 4.24 × 10−03 2.04 × 10−01 − 2.52 × 10−04 6.81 × 10−01
 ADAD and Controls 33 − 0.05 2.37 × 10−05 0.06 2.45 × 10−05 − 0.01 2.29 × 10−01 − 7.2 × 10−04 4.89 × 10−01
 LOAD and Controls 88 − 0.03 7.41 × 10−04 0.03 4.63 × 10−04 − 3.72 × 10−03 3.29 × 10−01 − 1.66 × 10−04 7.86 × 10−01
  1. aAD includes both autosomal dominant AD (ADAD) and late-onset AD (LOAD)
  2. The cellular population structure was inferred using the ssNMF method. Effects and p-values for the association with disease status, clinical dementia rating and Braak staging using generalized mixed models. We identified similar trends with approximately the same significance levels
  3. AD Alzheimer’s disease, ADAD autosomal dominant AD, LOAD late-onset AD