|
Disease status
|
Sample size
|
Neuron
|
Astrocyte
|
Oligodendrocyte
|
Microglia
|
|---|
| |
n
|
Effect
|
p value
|
Effect
|
p value
|
Effect
|
p value
|
Effect
|
p value
|
|---|
|
AD status
|
|
ADa vs Control
|
122
|
− 0.11
|
5.52 × 10−04
|
0.14
|
2.48 × 10−05
|
− 0.03
|
6.5 × 10−02
|
− 2.64 × 10−03
|
2.49 × 10−01
|
|
ADAD vs Control
|
38
|
− 0.19
|
3.94 × 10−07
|
0.24
|
1.57 × 10−10
|
− 0.04
|
8.5 × 10−03
|
− 0.01
|
7.77 × 10−05
|
|
LOAD vs Control
|
100
|
− 0.09
|
5.67 × 10−03
|
0.12
|
3.34 × 10−04
|
− 0.02
|
1.06 × 10−01
|
− 1.70 × 10−03
|
4.57 × 10−01
|
|
ADAD vs LOAD
|
|
Braak matched
|
42
|
− 0.08
|
1.03 × 10−02
|
0.11
|
9.26 × 10−04
|
− 0.03
|
7.1 × 10−02
|
− 1.46 × 10−03
|
7.01 × 10−01
|
|
Braak corrected
|
91
|
− 0.09
|
4.71 × 10−03
|
0.11
|
5.24 × 10−04
|
− 0.02
|
1.77 × 10−01
|
− 2.41 × 10−03
|
4.25 × 10−01
|
|
CDR corrected
|
94
|
− 0.12
|
2.11 × 10−03
|
0.13
|
6.29 × 10−04
|
− 0.02
|
3.8 × 10−01
|
− 3.11 × 10−03
|
2.41 × 10−01
|
|
Clinical Dementia Rating
|
|
ADa and Controls
|
110
|
− 0.02
|
2.66 × 10−02
|
0.03
|
5.48 × 10−03
|
− 0.01
|
2 × 10−01
|
− 4.63 × 10−04
|
4.77 × 10−01
|
|
ADAD and Controls
|
26
|
− 0.08
|
4.12 × 10−04
|
0.11
|
1.78 × 10−07
|
0.01
|
4.03 × 10−03
|
− 1.55 × 10−03
|
1.75 × 10−08
|
|
LOAD and Controls
|
100
|
− 0.02
|
3.22 × 10−02
|
0.03
|
7.01 × 10−03
|
− 0.01
|
1.81 × 10−01
|
− 4.64 × 10−04
|
5.11 × 10−01
|
|
Braak staging
|
|
ADa and Controls
|
106
|
− 0.03
|
8.51 × 10−06
|
0.03
|
3.83 × 10−06
|
− 4.24 × 10−03
|
2.04 × 10−01
|
− 2.52 × 10−04
|
6.81 × 10−01
|
|
ADAD and Controls
|
33
|
− 0.05
|
2.37 × 10−05
|
0.06
|
2.45 × 10−05
|
− 0.01
|
2.29 × 10−01
|
− 7.2 × 10−04
|
4.89 × 10−01
|
|
LOAD and Controls
|
88
|
− 0.03
|
7.41 × 10−04
|
0.03
|
4.63 × 10−04
|
− 3.72 × 10−03
|
3.29 × 10−01
|
− 1.66 × 10−04
|
7.86 × 10−01
|
- aAD includes both autosomal dominant AD (ADAD) and late-onset AD (LOAD)
- The cellular population structure was inferred using the ssNMF method. Effects and p-values for the association with disease status, clinical dementia rating and Braak staging using generalized mixed models. We identified similar trends with approximately the same significance levels
- AD Alzheimer’s disease, ADAD autosomal dominant AD, LOAD late-onset AD
