Table 3 Cellular population structure altered in the parietal lobe from AD brains in the DIAN study and Knight-ADRC brain bank
Disease status | Sample size | Neuron | Astrocyte | Oligodendrocyte | Microglia | ||||
|---|---|---|---|---|---|---|---|---|---|
n | Effect | p value | Effect | p value | Effect | p value | Effect | p value | |
AD status | |||||||||
ADa vs Control | 122 | − 0.11 | 5.52 × 10−04 | 0.14 | 2.48 × 10−05 | − 0.03 | 6.5 × 10−02 | − 2.64 × 10−03 | 2.49 × 10−01 |
ADAD vs Control | 38 | − 0.19 | 3.94 × 10−07 | 0.24 | 1.57 × 10−10 | − 0.04 | 8.5 × 10−03 | − 0.01 | 7.77 × 10−05 |
LOAD vs Control | 100 | − 0.09 | 5.67 × 10−03 | 0.12 | 3.34 × 10−04 | − 0.02 | 1.06 × 10−01 | − 1.70 × 10−03 | 4.57 × 10−01 |
ADAD vs LOAD | |||||||||
Braak matched | 42 | − 0.08 | 1.03 × 10−02 | 0.11 | 9.26 × 10−04 | − 0.03 | 7.1 × 10−02 | − 1.46 × 10−03 | 7.01 × 10−01 |
Braak corrected | 91 | − 0.09 | 4.71 × 10−03 | 0.11 | 5.24 × 10−04 | − 0.02 | 1.77 × 10−01 | − 2.41 × 10−03 | 4.25 × 10−01 |
CDR corrected | 94 | − 0.12 | 2.11 × 10−03 | 0.13 | 6.29 × 10−04 | − 0.02 | 3.8 × 10−01 | − 3.11 × 10−03 | 2.41 × 10−01 |
Clinical Dementia Rating | |||||||||
ADa and Controls | 110 | − 0.02 | 2.66 × 10−02 | 0.03 | 5.48 × 10−03 | − 0.01 | 2 × 10−01 | − 4.63 × 10−04 | 4.77 × 10−01 |
ADAD and Controls | 26 | − 0.08 | 4.12 × 10−04 | 0.11 | 1.78 × 10−07 | 0.01 | 4.03 × 10−03 | − 1.55 × 10−03 | 1.75 × 10−08 |
LOAD and Controls | 100 | − 0.02 | 3.22 × 10−02 | 0.03 | 7.01 × 10−03 | − 0.01 | 1.81 × 10−01 | − 4.64 × 10−04 | 5.11 × 10−01 |
Braak staging | |||||||||
ADa and Controls | 106 | − 0.03 | 8.51 × 10−06 | 0.03 | 3.83 × 10−06 | − 4.24 × 10−03 | 2.04 × 10−01 | − 2.52 × 10−04 | 6.81 × 10−01 |
ADAD and Controls | 33 | − 0.05 | 2.37 × 10−05 | 0.06 | 2.45 × 10−05 | − 0.01 | 2.29 × 10−01 | − 7.2 × 10−04 | 4.89 × 10−01 |
LOAD and Controls | 88 | − 0.03 | 7.41 × 10−04 | 0.03 | 4.63 × 10−04 | − 3.72 × 10−03 | 3.29 × 10−01 | − 1.66 × 10−04 | 7.86 × 10−01 |