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Fig. 2 | Genome Medicine

Fig. 2

From: KLRD1-expressing natural killer cells predict influenza susceptibility

Fig. 2

Differences in estimated cell type proportions between asymptomatic nonshedders and symptomatic shedders before infection. Immune cell proportions were estimated at baseline using cell mixture deconvolution. Forest plots of effect sizes of a NK cells (effect size = − 0.85, P = 0.012) and b HSPCs (effect size = 0.81, P = 0.017) in discovery cohorts. Positive effect sizes indicate higher levels while negative effect sizes indicate lower levels for that cell type in symptomatic shedders. The x axes represent standardized mean difference between symptomatic shedders and asymptomatic nonshedders, computed as Hedges’ g, in log2 scale. The size of the blue rectangles is proportional to the SEM difference in the study. Whiskers represent the 95% confidence interval. The yellow diamonds represent overall, combined mean difference for a given cell type. Width of the yellow diamonds represents the 95% confidence interval of overall mean difference. Violin plots of estimated cell proportions of c NK cells (effect size = − 1.18, P = 0.045) and d HSPCs (effect size = 0.79, P = 0.13) at baseline in validation cohort GSE61754. NK, natural killer. HSPC, hematopoietic stem and progenitor cells

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