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Fig. 6 | Genome Medicine

Fig. 6

From: KLRD1-expressing natural killer cells predict influenza susceptibility

Fig. 6

Estimated HSPC proportions decrease in blood and tissue during infection. HSPC proportions were estimated using cell mixture deconvolution in cohorts of acute viral infection. a Forest plot indicating the estimated proportion of HSPCs in the blood of individuals acutely infected with influenza compared to controls in cohorts of naturally acquired infection in cohorts obtained from GSE68310 and GSE61821 (summary effect size = − 2.0, P < 1e−13). b Forest plot indicating the proportions of HSPCs in the blood of individuals acutely infected with dengue, HRV, or RSV compared to controls (summary effect size = 0.5, P < 0.001). c Time course of HSPC proportions in the blood of individuals with naturally acquired influenza A infection. Baseline indicates a non-infected time point at the beginning of the study. Day 0 is within 48 h of symptom onset. d HSPC proportions in nasal scrapings before and after inoculation with rhinovirus (GSE11348). ef Correlation between the change in HSPCs between pre-infection and 48 h post-infection and the change in (e) M1 macrophages (r = − 0.84, P = 9.3e−5) and (f) mDCs (r = − 0.84, p = 8.5e−5) between pre-infection and 48 h post-infection. Pand. H1N1: 2009 Pandemic H1N1

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