Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease

Winchester, Laura M.; Powell, John; Lovestone, Simon; Nevado-Holgado, Alejo J.

doi:10.1186/s13073-018-0556-z

Table 1 Associations between blood traits and cognitive function tests as revealed by linear modelling

From: Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer’s disease

	Numeric beta	Numeric p	Reaction beta	Reaction p	Prospective beta	Prospective p	Reasoning beta	Reasoning p	Visual beta	Visual p
Red
RBC	− 0.085	0.019	− 0.012	8.86 × 10 ⁻¹⁴	0.011	0.642	− 0.089	2.39 × 10⁻⁵	− 0.013	0.063
HGB	0.026	0.056	− 0.009	6.67 × 10 ⁻⁴⁶	0.076	1.44 × 10 ⁻¹⁸	0.040	2.26 × 10 ⁻⁷	0.0004	0.884
HCT	0.002	0.701	− 0.002	8.78 × 10 ⁻³¹	0.020	6.97 × 10 ⁻¹²	0.005	0.045	0.0001	0.884
MCV	0.015	7.12 × 10 ⁻⁷	− 0.001	4.08 × 10⁻⁴	0.017	2.29 × 10 ⁻¹⁷	0.017	1.64 × 10 ⁻²²	0.002	3.15 × 10⁻⁴
MCH	0.036	1.53 × 10 ⁻⁷	− 0.002	8.45 × 10 ⁻⁸	0.042	1.44 × 10 ⁻¹⁸	0.044	1.92 × 10 ⁻²⁸	0.004	0.001
MCHC	0.033	0.004	− 0.003	7.94 × 10 ⁻⁸	0.041	1.15 × 10⁻⁵	0.048	7.33 × 10 ⁻¹²	0.001	0.787
RDW	− 0.055	1.27 × 10⁻⁴	0.009	1.23 × 10 ⁻³⁸	− 0.070	1.71 × 10 ⁻¹⁴	− 0.053	3.06 × 10 ^− 10	− 0.008	0.003
Immature red
RET%	− 0.016	0.442	0.001	0.227	− 0.021	0.100	− 0.018	0.104	− 0.001	0.812
RET	− 1.346	0.025	− 0.001	0.984	− 1.341	0.001	− 1.301	9.40 × 10⁻⁵	− 0.067	0.375
MRV	− 0.002	0.432	0.001	6.34 × 10 ⁻²¹	− 0.003	0.009	− 0.005	7.18 × 10 ⁻⁶	0.001	0.022
MSCV	0.002	0.512	0.001	2.58 × 10 ⁻⁷	0.001	0.642	− 0.001	0.413	0.002	4.24 × 10⁻⁴
IRF	− 0.857	1.41 × 10⁻⁴	0.066	3.70 × 10 ⁻¹⁰	− 0.784	4.05 × 10 ⁻⁷	− 0.544	5.97 × 10⁻⁵	− 0.077	0.083
NRBC	− 0.186	0.799	0.072	2.67 × 10⁻⁴	− 0.404	0.227	− 0.385	0.241	0.026	0.879
NRBC%	− 0.003	0.945	0.005	0.004	− 0.021	0.326	− 0.020	0.352	− 0.001	0.884
White
WBC	− 0.032	4.47 × 10 ⁻⁷	0.003	2.16 × 10 ⁻²⁴	− 0.010	0.020	− 0.020	2.06 × 10 ⁻⁸	− 0.003	0.013
PLT	− 0.0004	0.071	0.00004	1.53 × 10⁻⁴	0.000	0.020	0.000	0.825	0.000	0.273
PCT	− 0.802	0.008	0.053	6.28 × 10⁻⁵	− 0.668	0.001	− 0.187	0.344	− 0.142	0.010
MPV	− 0.016	0.214	− 0.00001	0.984	− 0.012	0.163	− 0.015	0.045	− 0.004	0.083
PDW	0.007	0.862	− 0.002	0.054	0.035	0.054	0.056	0.000	− 0.011	0.022
LYMPH	− 0.001	0.945	0.002	8.65 × 10⁻⁵	− 0.011	0.109	− 0.018	0.002	− 0.003	0.155
MONO	− 0.087	0.118	0.013	5.28 × 10 ⁻⁶	− 0.041	0.241	0.027	0.420	− 0.011	0.390
NEUT	− 0.061	3.15 × 10 ⁻¹¹	0.005	1.77 × 10 ⁻²⁶	− 0.009	0.155	− 0.031	1.90 × 10 ⁻⁸	− 0.004	0.036
EO	− 0.318	0.001	0.021	3.18 × 10 ⁻⁶	− 0.175	0.010	− 0.005	0.927	− 0.024	0.233
BASO	− 0.010	0.973	0.046	3.61 × 10⁻⁴	− 0.498	0.014	− 0.025	0.910	− 0.007	0.884
LYMPH%	0.005	0.009	− 0.0002	0.004246	− 0.004	0.002	− 0.003	0.003	− 0.0004	0.232
MONO%	0.012	0.011	− 0.001	0.012	0.003	0.326	0.013	1.44 × 10 ⁻⁷	0.0001	0.884
NEUT%	− 0.005	0.003	0.0002	0.003	0.003	0.005	0.0002	0.910	0.0003	0.294
EO%	− 0.005	0.593	0.0003	0.316	− 0.009	0.085	0.011	0.013	− 0.0004	0.884
BASO%	0.037	0.186	0.002	0.126	− 0.030	0.056	0.022	0.140	0.002	0.787

Highly significant results are marked with italic fonts (p < 10⁻⁵). See Abbreviations section for acronyms

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