Fig. 3

Different types of clusterization show concerted changes in the expression of spliceosomal and cell cycle genes. a–с Time clusterization of gene expression data (right panel) and subsequent pathway enrichment analysis (left panel) of clusters with highly represented spliceosomal genes. The clusters were constructed based on the following datasets: a E-GEOD-8057, b E-GEOD-18494, and c E-GEOD-59861. Blue lines represent z-score values of gene expression in each cluster. The red line is a mean value of z-score values of a cluster. d Graph representing the common transcription factor SOX2 that may induce concerted changes in the expression of pairs of mitotic and splicing genes after a course of chemotherapy. Solid black lines connect a pair of co-expressed genes, and red lines connect transcription factors with their target genes. Additional file 4: Figure S2A, B shows similar graphs for the transcription factors GFI1B and TARDBP