Fig. 6

Colocalization of eQTL and GWAS signatures. LocusZoom plots show the univariate SNP-wise association statistics for each genotyped SNP either with the abundance of the indicated trasncript (eQTL effects) or from the GWAS for IBD or RA. Color coding indicates the r² measure of linkage disequilibrium of each SNP with the relevant peak GWAS SNP. a rs12946510 is most likely a shared causal variant for ORMDL3 gene expression in both IBD and JIA, as well as in the IBD GWAS. However, a likely secondary signal in the light blue region is not associated with IBD. b rs2561477 is the peak causal variant in RA but clearly does not colocalize with the peak eQTL for JIA. c rs3740415 is most likely a shared causal variant for expression of TMEM180 and in the IBD GWAS despite an extensive LD block at the locus (though it does not meet the strict GWAS threshold)