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Fig. 5 | Genome Medicine

Fig. 5

From: Epigenomic profiling of non-small cell lung cancer xenografts uncover LRP12 DNA methylation as predictive biomarker for carboplatin resistance

Fig. 5

LRP12 DNA hypermethylation as independent predictive factor for clinical outcome in NSCLC. a LRP12 methylation level in FFPE samples of primary NSCLC tumors of the validation cohort with relapse (non-responders, n = 15) or without relapse (responders, n = 19, conversion efficiency > 3) determined by qMSP (Mann-Whitney test, p < 0.003). b Kaplan-Meier analysis of overall survival (OS) of the same cohort as used in a with respect to LRP12 methylation status (LRP12+ methylation > 8.3%, 16 patients; LRP12−, methylation < 8.3%, 19 patients). The statistical significance of the log-rank test is shown. The mean time to survival in years is indicated for each group. Confidence interval is marked in violet

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Genome Medicine

ISSN: 1756-994X

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