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Table 1 PAH-CHD patient population

From: Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease

  Pediatric Adult
Male, n (%) 53 (36.8) 24 (21.4)
Female, n (%) 91 (63.2) 88 (78.6)
Total, n (%) 144 (56.3) 112 (43.7)
Female-to-male ratio 1.7:1 3.7:1a
Ancestry, n (%)
 East Asian 7 (4.9) 7 (6.3)
 Hispanic 30 (20.8) 27 (24.1)
 African 13 (9) 6 (5.4)
 South Asian 10 (6.9) 7 (6.3)
 European 81 (56.3) 63 (56.3)
 Unknown 3 (2.1) 2 (1.8)
Primary cardiac defect, %
 Atrial septal defect (ASD) 33.8 55.7
 Ventricular septal defect (VSD) 22.5 17.7
 ASD + VSD 13.8 7.6
 Atrioventricular canal defect 7.5 6.3
 Tetralogy of Fallot 5.6 1.3
 Transposition of the great vessels 3.8 3.8
 Hypoplastic left heart syndrome 1.3 0
 Coarctation of the artery 0.6 0
 Other/complex 11.3 7.6
  1. aFisher’s exact test, p = 0.009, indicating a higher female-to-male ratio in adult-onset cases compared to pediatric-onset cases