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Table 1 Associations of EBV EBNA and rubella antigens with HLA (SNP, allele, and amino acid position)

From: Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

 

Phenotype

EBV EBNA IgG levels

Rubella IgG levels

SNP

 ID (Allele)

rs74951723 (A)

rs115118356 (G)

 P-value

3 × 10−14

7.68 × 10−10

 Beta (95% CI)

0.29 (0.21, 0.36)

−0.11 (− 0.15, − 0.08)

Classical HLA allele

 Allele

HLA-DQB1*03:01

HLA-DPB1*03:01

P value

1.26 × 10−7

3.8 × 10−6

 Beta (95% CI)

0.17 (0.11, 0.23)

− 0.12 (− 0.18, − 0.07)

Amino acid

 Protein (position)

HLA-DRβ1 (56)

HLA-DPβ1 (8)

 Omnibus P value

2.53 × 10−11

1.12 × 10−9