Skip to main content

Table 1 Associations of EBV EBNA and rubella antigens with HLA (SNP, allele, and amino acid position)

From: Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

  Phenotype
EBV EBNA IgG levels Rubella IgG levels
SNP
 ID (Allele) rs74951723 (A) rs115118356 (G)
 P-value 3 × 10−14 7.68 × 10−10
 Beta (95% CI) 0.29 (0.21, 0.36) −0.11 (− 0.15, − 0.08)
Classical HLA allele
 Allele HLA-DQB1*03:01 HLA-DPB1*03:01
P value 1.26 × 10−7 3.8 × 10−6
 Beta (95% CI) 0.17 (0.11, 0.23) − 0.12 (− 0.18, − 0.07)
Amino acid
 Protein (position) HLA-DRβ1 (56) HLA-DPβ1 (8)
 Omnibus P value 2.53 × 10−11 1.12 × 10−9