Fig. 3

Clinical relevance of OncoGenomic Landscapes. a Differences between TCGA and MSKCC cohorts related to resistance to endocrine therapy in PRAD and BRCA. The fraction of patients in each cohort presenting alterations in the androgen receptor (AR) and the estrogen receptor (ESR1) are shown in green and magenta, respectively. b Patient distance to PDXs correlates with overall survival probability. The territories occupied by PDXs are shown as a background landscape in gray scale whereas the location of patients that are proximal (red) or distal (blue) to PDXs are shown as transparent level plots. b Kaplan-Meyer analysis comparing the overall survival rate of patients that are proximal (red) or distal (blue) to PDXs. Panel a is composed of screenshots directly obtained from the webserver. Panel b was generated outside the app following the steps described in the tutorial available at https://oglandscapes.irbbarcelona.org/tutorial