Fig. 6
From: Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)
In vivo detection of rifampicin resistance mutations in a mouse persistence model. The heat maps represent quantification of RpoB mutants in kidney, liver and spleen of eight different mice after 1 or 7 days infection with a complex in vitro selected population (mice M1 to M4 on the left) or with a genetically defined population of rifampicin-resistant clones (mice M5 to M8). The columns labelled “inoc.” represent the initial inoculum. Grey and black boxes represent low and high relative allele abundance