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Table 2 Mutations in episodes with phenotypic changes

From: Genomic exploration of sequential clinical isolates reveals a distinctive molecular signature of persistent Staphylococcus aureus bacteraemia

Patient code Gene Type Mutation Product Category Significance
P_03 ptsG del G306fs (stop at residue 341/682) PTS system glucose-specific EIICBA component Carbohydrate transport and metabolism Three-component glucose transporter with phosphorylation activity [73]. ptsG deletion associated to resistance to glycosylated bacteriocins [74]
P_03 rpoB snp R503H DNA-directed RNA polymerase subunit beta Transcription R503H associated with VISA phenotype in vitro. No rifampicin resistance [52]
P_03 rplV complex AIN95GR 50S ribosomal protein L22 Translation, ribosomal structure and biogenesis Association with slow growth in in vitro selected VISA harbouring rpoB A621E [53]
P_03 rplD del KG68del 50S ribosomal protein L4 Translation, ribosomal structure and biogenesis Mutations at positions 68 and 69 associated with linezolid resistance [75] and macrolide resistance [76]
P_05 stp snp N137D Serine/threonine phosphatase stp Signal transduction mechanisms VISA phenotype in clinical strains; confirmed by mutagenesis [54, 55]
P_30 – del HVC139R hypothetical protein Function unknown  
P_30 ywlC snp A60D Threonylcarbamoyl-AMP synthase Translation, ribosomal structure and biogenesis Required for the attachment of a threonylcarbamoyl group to ANN-decoding tRNA [56]
  1. PTS phosphotransferase system, VISA vancomycin-intermediate Staphylococcus aureus, AMP adenosine monophosphate
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Genome Medicine

ISSN: 1756-994X

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