P_03
|
ptsG
|
del
|
G306fs (stop at residue 341/682)
|
PTS system glucose-specific EIICBA component
|
Carbohydrate transport and metabolism
|
Three-component glucose transporter with phosphorylation activity [73]. ptsG deletion associated to resistance to glycosylated bacteriocins [74]
|
P_03
|
rpoB
|
snp
|
R503H
|
DNA-directed RNA polymerase subunit beta
|
Transcription
|
R503H associated with VISA phenotype in vitro. No rifampicin resistance [52]
|
P_03
|
rplV
|
complex
|
AIN95GR
|
50S ribosomal protein L22
|
Translation, ribosomal structure and biogenesis
|
Association with slow growth in in vitro selected VISA harbouring rpoB A621E [53]
|
P_03
|
rplD
|
del
|
KG68del
|
50S ribosomal protein L4
|
Translation, ribosomal structure and biogenesis
|
Mutations at positions 68 and 69 associated with linezolid resistance [75] and macrolide resistance [76]
|
P_05
|
stp
|
snp
|
N137D
|
Serine/threonine phosphatase stp
|
Signal transduction mechanisms
|
VISA phenotype in clinical strains; confirmed by mutagenesis [54, 55]
|
P_30
|
–
|
del
|
HVC139R
|
hypothetical protein
|
Function unknown
| |
P_30
|
ywlC
|
snp
|
A60D
|
Threonylcarbamoyl-AMP synthase
|
Translation, ribosomal structure and biogenesis
|
Required for the attachment of a threonylcarbamoyl group to ANN-decoding tRNA [56]
|