Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Table 2 Top 20 differentially methylated positions between RA twins and non-RA twins. Probe names are shown, along with methylation levels, intra-pair methylation difference, unadjusted p value and probe annotation

Probe	Non-RA beta	RA beta	Diff	p value	Chr	Relationship to gene	Gene symbol
cg26547058	0.763	0.800	0.037	4.89E−07	8
cg07693617	0.758	0.788	0.030	5.15E−07	1	Body	PRKCZ
cg07636225	0.849	0.867	0.018	9.33E−07	11	Body	RTN3
cg03517226	0.709	0.716	0.007	1.18E−06	16	5′UTR	ANKRD11
cg20666386	0.184	0.180	−0.004	1.89E−06	11	1stExon	DGKZ
cg17501210	0.766	0.740	−0.026	2.54E−06	6	Body	RPS6KA2
cg26964117	0.775	0.796	0.021	2.56E−06	19	Body	PIH1D1
cg26701826	0.396	0.419	0.023	2.71E−06	4	5′UTR	SGMS2
cg06040872	0.810	0.822	0.012	2.92E−06	17	Body	CCL18
cg25487804	0.867	0.876	0.009	3.38E−06	11	TSS1500	OSBPL5
cg06128521	0.900	0.905	0.005	3.56E−06	17
cg16640599	0.421	0.447	0.026	3.58E−06	4	Body	SEC24D
cg02445229	0.719	0.737	0.018	3.85E−06	19
cg01769457	0.039	0.043	0.004	3.90E−06	1
cg15293582	0.704	0.703	−0.001	4.06E−06	10	TSS1500	PRF1
cg07090025	0.091	0.100	0.009	4.21E−06	1	TSS200	SSU72
cg06791979	0.795	0.799	0.004	4.44E−06	11	Body	RTN3
cg01934296	0.939	0.931	−0.008	4.45E−06	1	Body
cg26272088	0.819	0.838	0.019	4.54E−06	19	Body	IRGC
cg18460107	0.674	0.679	0.005	4.71E−06	17	TSS200	SEPT9

ISSN: 1756-994X