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Table 2 Top 20 differentially methylated positions between RA twins and non-RA twins. Probe names are shown, along with methylation levels, intra-pair methylation difference, unadjusted p value and probe annotation

From: Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Probe Non-RA beta RA beta Diff p value Chr Relationship to gene Gene symbol
cg26547058 0.763 0.800 0.037 4.89E−07 8   
cg07693617 0.758 0.788 0.030 5.15E−07 1 Body PRKCZ
cg07636225 0.849 0.867 0.018 9.33E−07 11 Body RTN3
cg03517226 0.709 0.716 0.007 1.18E−06 16 5′UTR ANKRD11
cg20666386 0.184 0.180 −0.004 1.89E−06 11 1stExon DGKZ
cg17501210 0.766 0.740 −0.026 2.54E−06 6 Body RPS6KA2
cg26964117 0.775 0.796 0.021 2.56E−06 19 Body PIH1D1
cg26701826 0.396 0.419 0.023 2.71E−06 4 5′UTR SGMS2
cg06040872 0.810 0.822 0.012 2.92E−06 17 Body CCL18
cg25487804 0.867 0.876 0.009 3.38E−06 11 TSS1500 OSBPL5
cg06128521 0.900 0.905 0.005 3.56E−06 17   
cg16640599 0.421 0.447 0.026 3.58E−06 4 Body SEC24D
cg02445229 0.719 0.737 0.018 3.85E−06 19   
cg01769457 0.039 0.043 0.004 3.90E−06 1   
cg15293582 0.704 0.703 −0.001 4.06E−06 10 TSS1500 PRF1
cg07090025 0.091 0.100 0.009 4.21E−06 1 TSS200 SSU72
cg06791979 0.795 0.799 0.004 4.44E−06 11 Body RTN3
cg01934296 0.939 0.931 −0.008 4.45E−06 1 Body  
cg26272088 0.819 0.838 0.019 4.54E−06 19 Body IRGC
cg18460107 0.674 0.679 0.005 4.71E−06 17 TSS200 SEPT9
  1. Chr chromosome