Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins

Table 3 Top 20 differentially variable positions between RA-affected and non-RA twins. Probe names are shown, along with t-statistic p value, Bartlett’s test for differential variability, which group was hypervariable, and probe annotation

Probe	P(tt)	P(BT)	Hypervariable group	Chr	Relationship to gene	Gene symbol
cg11374732	0.000513329	4.09E−06	RA	2	Body	INPP5D
cg01999539	0.000614047	1.50E−05	RA	6
cg23280983	0.000689806	2.11E−05	RA	2	TSS200	C2orf42
cg20500144	0.000950244	6.82E−05	RA	3	Body	ARL6IP5
cg26985354	0.001008386	2.18E−08	RA	19	Body	SFRS16
cg26827503	0.001032395	2.68E−05	RA	4	Body	TMEM156
cg11913894	0.001053694	2.93E−06	RA	6	TSS1500	MAP3K4
cg16583193	0.001125272	4.49E−06	RA	19	Body	PIP5K1C
cg15573998	0.001139278	3.52E−05	RA	2	Body	NRXN1
cg16012388	0.001186516	5.35E−06	RA	10	Body	BICC1
cg16397722	0.00119032	9.50E−06	RA	17	Body	TP53
cg20556304	0.001192582	3.94E−11	RA	6
cg25173129	0.00134302	2.51E−07	Healthy	17	TSS1500	EPX
cg01928104	0.001384944	3.10E−06	RA	14	TSS1500	SNORD114-7
cg06734169	0.001534366	4.20E−07	RA	3	5′UTR	LRRFIP2
cg04845047	0.00156418	4.88E−05	RA	13
cg26788916	0.001792861	7.32E−05	RA	20
cg00340024	0.001861004	3.01E−05	RA	1
cg08306614	0.001980509	1.42E−05	RA	7	3′UTR	NUDCD3
cg19929189	0.001981039	3.59E−09	RA	6

ISSN: 1756-994X