TY - JOUR AU - Pogorelyy, Mikhail V. AU - Fedorova, Alla D. AU - McLaren, James E. AU - Ladell, Kristin AU - Bagaev, Dmitri V. AU - Eliseev, Alexey V. AU - Mikelov, Artem I. AU - Koneva, Anna E. AU - Zvyagin, Ivan V. AU - Price, David A. AU - Chudakov, Dmitry M. AU - Shugay, Mikhail PY - 2018 DA - 2018/08/25 TI - Exploring the pre-immune landscape of antigen-specific T cells JO - Genome Medicine SP - 68 VL - 10 IS - 1 AB - Adaptive immune responses to newly encountered pathogens depend on the mobilization of antigen-specific clonotypes from a vastly diverse pool of naive T cells. Using recent advances in immune repertoire sequencing technologies, models of the immune receptor rearrangement process, and a database of annotated T cell receptor (TCR) sequences with known specificities, we explored the baseline frequencies of T cells specific for defined human leukocyte antigen (HLA) class I-restricted epitopes in healthy individuals. SN - 1756-994X UR - https://doi.org/10.1186/s13073-018-0577-7 DO - 10.1186/s13073-018-0577-7 ID - Pogorelyy2018 ER -