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Fig. 4 | Genome Medicine

Fig. 4

From: Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Fig. 4

Identification of immune checkpoint-specific genes expressed by CD4+ T cells in rejecting and tolerated grafts. Jitter plots comparing expression levels of a stimulatory and b inhibitory immune checkpoint-specific genes expressed by CD4+hCD2 Th of rejecting grafts (R-TH), CD4+hCD2+ Treg of rejecting grafts (R-TR), CD4+hCD2 Th of tolerated grafts (T-TH), and CD4+hCD2+ Treg of tolerated grafts (T-TR). The fold change (FC) of T-TR over R-TR and the p value (P) by sSeq method are provided. Gray and black bars indicate the average expression level among all and expressed cells, respectively

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