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Fig. 2 | Genome Medicine

Fig. 2

From: Genotype effects contribute to variation in longitudinal methylome patterns in older people

Fig. 2

Enrichment analysis of rsCpGs in different CpG regions based on the permutation test. For each CpG region, the distribution of odds ratio based on permuted data (30,000 times) and the odds ratio based on the original data (red dashed line) are presented. DMR: differentially methylated region; CDMR: cancer-specific DMR; RDMR: reprogramming-specific DMR; NONE_DMR other CpGs not in DMR. Island: CpG island provided by UCSC [28]; N_Shore: 0–2 Kb upstream of CpG island; S_Shore: 0–2 Kb downstream of CpG island; N_Shelf: 2–4 Kb upstream of CpG island; S_Shelf: 2–4 Kb downstream of CpG island; Sea: 4 Kb away from CpG island. Enhancer: Predicted enhancer elements determined by ENCODE Consortium [46]

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