Fig. 3
From: Genotype effects contribute to variation in longitudinal methylome patterns in older people
a The distribution of estimated heritability of 1507 rsCpGs and all probes. The heritability of rsCpGs is normally distributed, with a mean of 0.40 (SD = 0.21). It is significantly larger (P < 3.3 × 10−5, permutation test, 30,000 times) than the overall level. No significant correlation (R = − 0.005, P = 0.27) was found between heritability of probes and the distance to their meQTLs [47]. However, there is a small but significant association (R = 0.07, P < 2.2 × 10−16) between the heritability and the mean phenotypic correlation (R2) between a target probe and other probes on the same chromosome. This indicated that CpG sites with substantial heritability could contribute to the estimation of heritability of other CpG sites that they correlate with. b An example to show the significant association between SNP dosage and the random slope of DNA methylation