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Table 2 Factors contributing to variance between microbial communities

From: Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers

 

Marginal

Adjusted

Factors

% Variation

p value

% Variation

p value

MMR status

2.58

0.001

1.85

0.004

Sample location—proximal/distal

1.87

0.011

1.44

0.019

Sample type

1.70

0.001

1.36

0.001

Sample location—on/off tumor

1.50

0.001

1.01

0.001

Sex

1.48

0.051

1.14

0.184

BMI

1.34

0.108

1.60

0.025

Age

0.96

0.542

1.02

0.319

  1. Percent variation and p values in the first two columns were from marginal analyses (i.e., not adjusted for other factors). Percent variation and p values in the last two columns were from analyses adjusting for all factors. Permutation tests (999 permutations) were used to calculate the p values. For “Sample type” and “on/off tumor” factors, the permutation was confined within the subject. For the rest of the factors, the subjects were the permutation units (i.e., randomly assign a value to each subject) to account for the within-subject correlations