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Fig. 4 | Genome Medicine

Fig. 4

From: Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

Fig. 4

Genome-wide chromatin occupancy of XBP1 transcription factor in Th2 lymphocyte. XBP1 ChIPmentation was performed in in vitro differentiated Th2 cells to obtain genome-wide XBP1 chromatin occupancy. a Snapshot of XBP1 binding peaks around indicated representative genes from the UCSC genome browser. b Genomic distribution of XBP1 binding peaks. The sector corresponding to the promoter includes sequences up to 1 kb upstream and 100 bp downstream from the TSS. c Comparing the XBP1 motifs from the JASPAR database (top), ChIP-seq of the human breast cancer cell lines (middle), and mouse Th2 lymphocytes (bottom). d Motif frequencies of XPB1 and NF-Y around the binding peaks of XBP1. e Biological processes’ GO terms enriched within XBP1 binding peaks analyzed by GREAT

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