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Fig. 5 | Genome Medicine

Fig. 5

From: Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

Fig. 5

Integration of ChIPmentation and RNA-seq data reveals XBP1 direct target genes and its regulatory network. a Venn diagram comparing previously reported XBP1 target genes of other secretory cell types with the Th2 direct target genes of this study. XBP1 direct target genes of this study are those that are common in both “XBP1-occupied genes in Th2” and “Differentially expressed genes (Th2 → Th2+4μ8c)” categories. The XBP1 direct target genes of B cell/plasma cell, skeletal muscle cells, and pancreatic β-cells were as observed by Acosta-Alvear et al. [17] and have been used here for comparison. b Heatmap showing the pattern of XBP1 direct target gene expression. The top 38 genes that follow a distinct pattern have been displayed. c Transcriptional regulatory network: transcription factors that are direct target of XBP1. The genes in the network are differentially expressed (upregulated—red; downregulated—blue) up on 4μ8c treatment. The transcription factors that are not differentially expressed but have a XBP1 ChIPseq peak are shown in the right-hand side list

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