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Fig. 6 | Genome Medicine

Fig. 6

From: Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors

Fig. 6

Recurrent ESR1-CCDC170 gene fusion in exceptional short-term surviving HGSOC. a Schematic diagram of the exons from ESR1 and CCDC170 included within the detected gene-fusion mRNA by RNA-seq in the two HGSOC primary tumor tissues from exceptionally short-term surviving patients. Diagram of protein domains encoded by the retained exons is shown for each fusion. b RNA-seq reads supporting the ESR1-CCDC170 fusion mRNA in patient LTS-034. c RNA-seq reads supporting the ESR1-CCDC170 fusion mRNA in patient LTS-002. Portions of the junction-spanning reads that align to the reference sequence of ESR1 and CCDC170 are colored in grey and the mismatched bases are shown in color

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