Fig. 5

Analysis of differential effects of actionable mutations on protein profiles across cancers. Protein profiles are compared for cases with and without the respective actionable mutations. For certain cases, the presence of an actionable mutation has no visible effect on the level or proteins (red), for other cases (green) protein profiles are distinguishable for mutated vs. wild-type cases. Among these, pairs of four actionable genes and 11 cancer types exist, where the actionable mutations have a similar/same directional effect on protein profiles across cancers (blue) suggesting a similar (patho)mechanistic effect of the actionable mutations in these histological tumor types (compare also Fig. 6)