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Fig. 2 | Genome Medicine

Fig. 2

From: Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer

Fig. 2

Entinostat inhibits luminal breast cancer through Myc signaling. a 563 upregulated and 565 downregulated genes with false positive rate (FDR) of 0% were hierarchically clustered using 817 TCGA breast cancer samples. We defined “signatures” as any gene set that contained a minimum of 10 genes and a Pearson node correlation greater than 0.5 in TCGA dataset. Using these criteria, we defined six and three signatures in upregulated and downregulated genes, respectively. b The summary of the characteristics of all signatures

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Genome Medicine

ISSN: 1756-994X

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